Cowboys vs. Panthers Week 6 Predictions, Odds and Stats

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In the game between the Carolina Panthers and Dallas Cowboys on Sunday, Oct. 12 at 1 p.m. ET, our projection system expects the Panthers to emerge victorious. Looking for predictions on the final score, spread, and point total, too? Find a complete game projection below.

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Cowboys vs. Panthers Game Info and TV Channel

  • When: Sunday, October 12, 2025 at 1 p.m. ET
  • Where: Bank of America Stadium in Charlotte, North Carolina
  • TV: FOX
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Listen to the game on 99.7 The Fox

Cowboys vs. Panthers Odds and Betting Info

  • Spread favorite: Cowboys (-3)
  • Moneyline: Cowboys (-166), Panthers (+138)
  • Total: 48.5 points

Cowboys vs. Panthers Prediction

  • Pick ATS: Panthers (+3)
  • Pick OU: Over (48.5)

Prediction:

Panthers 29 - Cowboys 23

    Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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    Cowboys vs. Panthers Betting Insights

    • The Cowboys have compiled a 3-2-0 record against the spread this season.
    • The Panthers have put together a 3-2-0 record against the spread this year.
    • Dallas has not covered the spread this season (0-1 ATS) when playing as at least 3-point favorites.
    • Carolina has covered the spread twice as an underdog by 3 points or more this season (in four opportunities).
    • The Cowboys and their opponent have combined to go over the point total three out of five times this season.
    • The Panthers and their opponent have combined to hit the over three out of five times this season.

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