Photo: Ron Jenkins / Getty Images Sport / Getty Images
The Clemson Tigers (3-3) and the SMU Mustangs (4-2) play on Saturday, October 18, 2025 at Memorial Stadium (Clemson, SC) in a clash of ACC foes.
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Clemson vs. SMU Matchup Info
- Game date: Saturday, October 18, 2025
- Game time: 3:30 p.m. ET
- Location: Clemson, South Carolina
- Venue: Memorial Stadium (Clemson, SC)
- TV channel: ACC Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Clemson vs. SMU Odds and Prediction
- Spread favorite: Tigers (-5.5)
- Moneyline: Tigers (-204), Mustangs (+168)
- Total: 50.5 points
- Pick ATS: SMU (+5.5)
- Pick OU: Over (50.5)
- Prediction: Clemson 27, SMU 24
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Clemson vs. SMU Betting Records and Insights
- Clemson has won two games against the spread this season.
- SMU has covered just once in five games with a spread this season.
- The Tigers have covered the spread twice this season (2-2 ATS) when playing as at least 5.5-point favorites.
- The Mustangs have not covered the spread this season (0-1 ATS) when playing as at least 5.5-point underdogs.
- This season, games featuring the Clemson have hit the over twice.
- Games featuring SMU have gone over the point total just once this season.