Photo: Todd Kirkland / Getty Images Sport / Getty Images
Our computer model predicts the San Francisco 49ers will defeat the Atlanta Falcons on Sunday, Oct. 19 at 8:20 p.m. ET. For a complete projection on the matchup at Levi's Stadium, which includes our prediction on the spread, over/under, and final score, keep scrolling.
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49ers vs. Falcons Game Info and TV Channel
- When: Sunday, October 19, 2025 at 8:20 p.m. ET
- Where: Levi's Stadium in Santa Clara, California
- TV: NBC
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Listen to the game on 107.7 The Bone
49ers vs. Falcons Odds and Betting Info
- Spread favorite: 49ers (-1.5)
- Moneyline: 49ers (-131), Falcons (+110)
- Total: 47.5 points
49ers vs. Falcons Prediction
- Pick ATS: 49ers (-1.5)
- Pick OU: Under (47.5)
Prediction:
49ers 24 - Falcons 17
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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49ers vs. Falcons Betting Insights
- The 49ers have put together a 3-3-0 record against the spread this season.
- The Falcons have put together a 3-2-0 record against the spread this season.
- San Francisco has been favored by 1.5 points or more four times this season, and covered the spread in two of those contests.
- Atlanta has covered the spread twice as an underdog by 1.5 points or more this season (in three opportunities).
- So far this season, four out of the 49ers' six games have hit the over.
- Falcons games have hit the over just once this year.
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